Advances and Application of Genomics in Chronic Obstructive Pulmonary Disease.
10.3881/j.issn.1000-503X.13784
- Author:
Lin-Fan SU
1
;
Hong-Mei ZHAO
2
;
Yi XIAO
1
Author Information
1. Department of Respiratory and Critical Care Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
2. State Key Laboratory of Medical Molecular Biology,Department of Pathophysiology,Institute of Basic Medical Sciences, CAMS and PUMC,Beijing 100005,China.
- Publication Type:Review
- Keywords:
chronic obstructive pulmonary disease;
genome-wide association study;
susceptibility gene
- MeSH:
Genome-Wide Association Study/methods*;
Genomics;
Humans;
Pulmonary Disease, Chronic Obstructive/genetics*
- From:
Acta Academiae Medicinae Sinicae
2022;44(4):668-672
- CountryChina
- Language:Chinese
-
Abstract:
Chronic obstructive pulmonary disease (COPD) is a common and frequently-occurring disease in the department of respiratory medicine,the pathogenesis of which involves both environmental factors and genetic factors.In recent years,with the application of new methods such as genome-wide association study,researchers have discovered a large number of gene mutations associated with lung function and COPD,providing a new perspective on the pathogenesis of COPD and potential therapeutic targets.This article reviews the research achievements and application progress of genomics in COPD.
