Correlation between Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Signaling Pathway and Non-infectious Diseases.
10.3881/j.issn.1000-503X.13745
- Author:
Hua-Xiang YU
1
;
Hai-Ying RUI
1
;
Zi-Qi HAN
1
;
Ruo-Chuan LI
1
;
Lu-Lu LIU
1
;
Li XUE
1
;
Yu-Guo CHEN
1
Author Information
1. Shandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine,Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province,Key Laboratory of Emergency and Critical Care Medicine of Shandong Province,Institute of Emergency and Critical Care Medicine of Shandong University,Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine,Emergency Medicine and Chest Pain Center, Qilu Hospital of Shandong University,Jinan 250012,China.
- Publication Type:Review
- Keywords:
cGAMP;
cyclic GMP-AMP synthase-stimulator of interferon genes;
cytoplasmic DNA;
inflammation;
non-infectious diseases
- MeSH:
Humans;
Interferons;
Membrane Proteins/metabolism*;
Noncommunicable Diseases;
Nucleotides, Cyclic;
Nucleotidyltransferases/metabolism*;
Signal Transduction
- From:
Acta Academiae Medicinae Sinicae
2022;44(4):661-667
- CountryChina
- Language:Chinese
-
Abstract:
As a DNA receptor in the cytoplasm,cyclic GMP-AMP synthase (cGAS) can recognize abnormal DNA in the cytoplasm and activate stimulator of interferon genes (STING) to regulate the immune response. The recent studies have demonstrated that this pathway plays a role in non-infectious inflammatory diseases by promoting the expression of type Ⅰ interferon and interferon-stimulated gene.This article reviews the activation and regulation of cGAS-STING pathway in multiple systems and the effect of this pathway on the occurrence and progression of non-infectious inflammatory diseases,providing theoretical reference for future application of cGAS-STING pathway-related drugs in non-infectious inflammatory diseases.
