Precision oncology from a proteogenomics perspective.

Author: Yurou HUANG ¹ ; Songfeng WU ² ; Kunxian SHU ¹ ; Yunping ZHU ²
Author Information

1. School of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, China.
2. National Center for Protein Sciences (Beijing), Beijing Institute of Life Omics, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 102206, China.
Publication Type:Journal Article
Keywords: cancer; precision oncology; proteogenomics; public database
MeSH: Humans; Proteogenomics; Precision Medicine; Neoplasms/genetics*; Proteomics; Genomics
From: Chinese Journal of Biotechnology 2022;38(10):3616-3627
CountryChina
Language:Chinese
Abstract: Cancer is a heterogeneous disease with complex mechanisms that requires targeted precision medicine strategies. The growth of precision medicine is indispensable from the rapid development of genomics. However, genomics has certain limitations in molecular phenotype analysis, proteogenomics thus arose at the right time. Proteogenomics is the merging of proteomics and genomics. This review describes the limitations of genomic analysis and highlights the importance of proteogenomics to re-understand precision oncology from a proteogenomic perspective. In addition, the application of proteogenomics in precision oncology is briefly introduced, the related public data projects are described, and finally, the challenges that need to be addressed at this stage are proposed.