Microneedle-based percutaneous immunity: a review.

Author: Yue LI ¹ ; Jing WANG ¹ ; Zhiying JIN ¹ ; Wei WAN ¹ ; Xuexin BAI ¹ ; Chenyi HU ¹ ; Yanwei LI ¹ ; Wenwen XIN ¹ ; Lin KANG ¹ ; Hao YANG ¹ ; Jinglin WANG ¹ ; Shan GAO ¹
Author Information

1. Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Publication Type:Review
Keywords: citespace; microneedle; percutaneous immunity; vaccine
MeSH: Administration, Cutaneous; Drug Delivery Systems; Needles; Vaccination; Vaccines
From: Chinese Journal of Biotechnology 2022;38(9):3301-3315
CountryChina
Language:Chinese
Abstract: Microneedle percutaneous immunization is achieved by puncturing the stratum corneum of the skin with microneedles so that the vaccine is efficiently recognized by antigen-presenting cells to induce a specific immune response. Due to the advantages of efficient induction of immune response, low pain and easy storage, transdermal immunization by microneedles has been widely used for immunization of various vaccines in recent years. This review summarizes the materials of microneedles, application for transcutaneous immunization, as well as the challenges that need to be addressed.