Advances of long non-coding RNA encoded micro-peptides.
- Author:
Jianfeng PAN
1
;
Fangzheng SHANG
1
;
Rong MA
1
;
Min WANG
1
;
Youjun RONG
1
;
Lili LIANG
1
;
Shuran NIU
1
;
Yanbo LI
1
;
Yunpeng QI
1
;
Yanjun ZHANG
1
;
Jinquan LI
2
Author Information
- Publication Type:Review
- Keywords: cancer; embryonic development; inflammation; long non-coding RNA; micro-peptide; muscle physiology; short open reading frames
- MeSH: Animals; Humans; Neoplasms/therapy*; Open Reading Frames; Peptides/chemistry*; RNA, Long Noncoding/genetics*
- From: Chinese Journal of Biotechnology 2022;38(9):3194-3214
- CountryChina
- Language:Chinese
- Abstract: Long non-coding RNA (lncRNA) refers to non-coding RNA longer than 200 nt, with one or more short open reading frames (sORF), which encode functional micro-peptides. These functional micro-peptides often play key roles in various biological processes, such as Ca2+ transport, mitochondrial metabolism, myocyte fusion, cellular senescence and others. At the same time, these biological processes play a key role in the regulation of body homeostasis, diseases and cancers development and progression, embryonic development and other important physiological processes. Therefore, studying the potential regulatory mechanisms of micro-peptides encoded by lncRNA in organisms will help to further elucidate the potential regulatory processes in organisms. Furthermore, it will provide a new theoretical basis for the subsequent targeted treatment of diseases and improvement of animal growth performance. This review summarizes the latest research progress in the field of lncRNA-encoded micro-peptides, as well as the progress in the fields of muscle physiological regulation, inflammation and immunity, common human cancers, and embryonic development. Finally, the challenges of lncRNA-encoded micro-peptides are briefly described, with the aim to facilitate subsequent in-depth research on micro-peptides.
