Research progress of c-di-GMP in the regulation of <i>Escherichia coli</i> biofilm.

Author: Yunjiang HE ¹ ; Weijuan JIA ¹ ; Shanshan CHI ¹ ; Qinglei MENG ¹ ; Yunjiao CHEN ¹ ; Xueli WANG ¹
Author Information

1. Animal Science and Technology College, Inner Mongolia Minzu University, Tongliao 028000, Inner Mongolia, China.
Publication Type:Journal Article
Keywords: Escherichia coli; biofilm; c-di-GMP; second messenger
MeSH: Bacterial Proteins/genetics*; Biofilms; Cyclic GMP/analogs & derivatives*; Escherichia coli/metabolism*; Escherichia coli Proteins/metabolism*; Gene Expression Regulation, Bacterial
From: Chinese Journal of Biotechnology 2022;38(8):2811-2820
CountryChina
Language:Chinese
Abstract: Escherichia coli biofilm is a complex membrane aggregation produced by the adhesion and secretion of extracellular polymeric substances by E. coli cells aggregated on specific media. Pathogenic E. coli will evade the immune system and the impact of various harmful factors in the environment after the formation of biofilm, causing sustained and even fatal damage to the host. Cyclic diguanosine monophosphate (c-di-GMP) is a second messenger ubiquitous in bacteria and plays a crucial role in regulating biofilm formation. This paper reviewed the recent studies about the role of c-di-GMP in the movement, adhesion, and EPS production mechanism of E. coli during biofilm formation, aiming to provide a basis for inhibiting E. coli biofilm from the perspective of c-di-GMP.