Advances in albicidin.
- Author:
Lilan CHEN
1
;
Haibin HUANG
1
;
Runtian BIAN
1
;
Zuhu DENG
1
;
Sanji GAO
1
;
Huili ZHANG
1
Author Information
- Publication Type:Review
- Keywords: Xanthomonas albilineans; albicidin; antibiotics; biosynthesis; chemical synthesis; phytotoxin; sugarcane leaf scald
- MeSH: Anti-Bacterial Agents/pharmacology*; China; Humans; Organic Chemicals; Xanthomonas/genetics*
- From: Chinese Journal of Biotechnology 2022;38(8):2738-2753
- CountryChina
- Language:Chinese
- Abstract: Xanthomonas albilineans (Ashby) Downson is a quarantine pest for importing plants to China that causes leaf scald bacterial disease on sugarcane. X. albilineans produces a potent phytotoxin/antibiotic called albicidin. As a pathogenic factor, albicidin causes typical white leaf stripes by inhibiting plastid DNA gyrase and disturbing chloroplast differentiation. Meanwhile, the antibacterial activity of albicidin gives X. albilineans a competitive advantage against rival bacteria during their colonization. Furthermore, albicidin has a rapid bactericidal activity against a variety of Gram-positive and Gram-negative pathogenic bacteria of human species at nanomolar concentrations, making it a potential antimicrobial drug for clinical application. This article reviews the advances of albicidin from the aspects of its molecular structure, traditional extraction methods, mechanism of action, biosynthetic genes and processes, chemical synthesis method and improvement, in order to provide insights into the prevention and treatment of the sugarcane leaf scald disease, and the development of new antibiotics.
