Mechanisms of microRNA action in rectal cancer radiotherapy.
10.1097/CM9.0000000000002139
- VernacularTitle:Mechanisms of microRNA action in rectal cancer radiotherapy
- Author:
Lili ZHU
1
;
Mojin WANG
1
;
Na CHEN
2
;
Yujie ZHANG
1
;
Tao XU
1
;
Wen ZHUANG
1
;
Shuomeng XIAO
3
;
Lei DAI
2
Author Information
1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
2. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.
3. Department of Gastrointestinal Surgery, Sichuan Cancer Hospital and Institute, Chengdu, Sichuan 610041, China.
- Publication Type:Journal Article
- MeSH:
Humans;
MicroRNAs/metabolism*;
Neoplasm Recurrence, Local;
Rectal Neoplasms/pathology*;
Neoadjuvant Therapy;
Radiation Tolerance/genetics*
- From:
Chinese Medical Journal
2022;135(17):2017-2025
- CountryChina
- Language:English
-
Abstract:
Preoperative neoadjuvant chemoradiotherapy, combined with total mesorectal excision, has become the standard treatment for advanced localized rectal cancer (RC). However, the biological complexity and heterogeneity of tumors may contribute to cancer recurrence and metastasis in patients with radiotherapy-resistant RC. The identification of factors leading to radioresistance and markers of radiosensitivity is critical to identify responsive patients and improve radiotherapy outcomes. MicroRNAs (miRNAs) are small, endogenous, and noncoding RNAs that affect various cellular and molecular targets. miRNAs have been shown to play important roles in multiple biological processes associated with RC. In this review, we summarized the signaling pathways of miRNAs, including apoptosis, autophagy, the cell cycle, DNA damage repair, proliferation, and metastasis during radiotherapy in patients with RC. Also, we evaluated the potential role of miRNAs as radiotherapeutic biomarkers for RC.
