Tumor microenvironment in lung cancer-derived brain metastasis.
10.1097/CM9.0000000000002127
- Author:
Wenwen LIU
1
;
Charles A POWELL
2
;
Qi WANG
1
Author Information
1. Translational Research Center for Lung Cancer, The Second Hospital, Dalian Medical University, Dalian, Liaoning 116023, China.
2. Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
- Publication Type:Review
- MeSH:
Brain Neoplasms/pathology*;
Humans;
Lung Neoplasms/drug therapy*;
Neoplasm Metastasis;
Tumor Microenvironment
- From:
Chinese Medical Journal
2022;135(15):1781-1791
- CountryChina
- Language:English
-
Abstract:
Brain metastasis (BM) is the leading cause of mortality in lung cancer patients. The process of BM (from initial primary tumor development, migration and intravasation, dissemination and survival in the bloodstream, extravasation, to colonization and growth to metastases) is a complex process for which few tumor cells complete the entire process. Recent research on BM of lung cancer has recently stressed the essential role of tumor microenvironment (TME) in assisting tumor cells in the completion of each BM step. This review summarizes recent studies regarding the effects of TME on tumor cells in the entire process of BM derived from lung cancer. The identification of vulnerable targets in the TME and their prospects to provide novel therapeutic opportunities are also discussed.
