Effect of acupuncture on dry eye and tear inflammatory factors.
10.13703/j.0255-2930.20220318-0001
- Author:
Zhong-Si LIN
1
;
Dong-Song YU
1
;
Jin-Long ZHAO
1
;
Hui-Yang SHI
2
;
Zhu-Qiang ZHANG
2
;
Lei ZHAO
2
;
Pin JU
3
Author Information
1. Shandong College of TCM, Yantai 264199, China.
2. Department of Ophthalmology, Second Affiliated Hospital of Liaoning University of TCM.
3. Graduate School of Liaoning University of TCM, Shenyang 110032.
- Publication Type:Journal Article
- Keywords:
acupuncture;
dry eye;
inflammatory factor;
randomized controlled trial (RCT);
secretion of tears
- MeSH:
Humans;
Hyaluronic Acid;
Interleukin-6;
Tumor Necrosis Factor-alpha;
Dry Eye Syndromes/therapy*;
Ophthalmic Solutions
- From:
Chinese Acupuncture & Moxibustion
2022;42(12):1379-1383
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:On the basis of sodium hyaluronate eye drops, to observe the clinical efficacy of acupuncture on dry eye and explore the effect mechanism of ocular surface protection.
METHODS:A total of 80 patients with dry eye were randomly divided into an observation group and a control group, 40 cases in each group. The control group was treated with routine cleaning of eyelid margin, hot compress of eyes with warm towel, and external application of sodium hyaluronate eye drops for 5 weeks. On the basis of the treatment as the control group, the observation group was treated with acupuncture at Jingming (BL 1), Cuanzhu (BL 2), Chengqi (ST 1), Hegu (LI 4), Zusanli (ST 36), Sanyinjiao (SP 6), etc., once a day, 6 times a week for 5 weeks (30 times totally). Before and after treatment, SchirmerⅠtest (SⅠT), breaking up time (BUT), corneal fluorescent (FL) score, ocular surface disease index (OSDI) score, and the contents of IL-6 and TNF-α in tears were evaluated and the therapeutic effect was compared between the two groups.
RESULTS:Compared with before treatment, SⅠT and BUT after treatment in the observation group were prolonged (P<0.05), the scores of FL and OSDI and the contents of IL-6 and TNF-α in tears were decreased (P<0.05). After treatment, SⅠT and BUT in the observation group were longer than the control group (P<0.05), and the scores of FL and OSDI and the contents of IL-6 and TNF-α in tears in the observation group were lower than the control group (P<0.05). The total effective rate in the observation group was 87.5% (35/40), which was higher than 45.0% (18/40) in the control group (P<0.05).
CONCLUSION:On the basis of sodium hyaluronate eye drops, acupuncture could improve the clinical symptoms of dry eye, promote the secretion of tears, prolong the tear film breaking up time, and reduce corneal damage, and effect mechanism may be related to the reduction of inflammatory response.
