Clinical observation on acupuncture for symptom burden in gastric cancer patients undergoing adjuvant chemotherapy after gastrectomy.
10.13703/j.0255-2930.20211106-k0004
- Author:
Xue-Song CHANG
1
;
Yan-Juan ZHU
2
,
3
,
4
;
Jian-Jun PENG
5
;
Xiao-Yu WU
6
;
Wei WANG
1
;
Yi-Hong LIU
1
;
Dan-Dan ZHAN
7
;
Ya-Dong CHEN
1
;
Hai-Bo ZHANG
2
,
3
,
8
,
9
Author Information
1. Guangdong Provincial Hospital of TCM, Second Affiliated Hospital of Guangzhou University of CM, Guangzhou 510120, China.
2. Guangdong Provincial Hospital of TCM, Second Affiliated Hospital of Guangzhou University of CM, Guangzhou 510120, China
3. Guangdong Provincial Key Laboratory of Clinical Research on TCM Syndrome
4. Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research.
5. First Affiliated Hospital, Sun Yat-sen University.
6. Jiangsu Province Hospital of CM/Affiliated Hospital of Nanjing University of Chinese Medicine.
7. Second Clinical Medical College of Guangzhou University of CM.
8. Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research
9. State Key Laboratory of Dampness Syndrome of Chinese Medicine.
- Publication Type:Journal Article
- Keywords:
acupuncture;
adjuvant chemotherapy;
frequency of treatment;
gastric cancer;
randomized controlled trial (RCT);
symptom burden
- MeSH:
Humans;
Acupuncture Points;
Stomach Neoplasms/surgery*;
Acupuncture Therapy;
Gastrectomy/adverse effects*;
Chemotherapy, Adjuvant
- From:
Chinese Acupuncture & Moxibustion
2022;42(11):1226-1232
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy of acupuncture on symptom burden in patients with gastric cancer during adjuvant chemotherapy after gastrectomy.
METHODS:A total of 58 patients were randomized into a high-dose acupuncture group (19 cases, 5 cases dropped off), a low-dose acupuncture group (20 cases, 6 cases dropped off) and a control group (19 cases, 2 cases dropped off). Conventional chemotherapy and antiemetic treatment were adopted in the control group. On the basis of the treatment in the control group, acupuncture was applied 7 times each chemotherapy cycle for totally 21 times in the high-dose acupuncture group, and 3 times each chemotherapy cycle for totally 9 times in the low-dose acupuncture group. Baihui (GV 20), Zusanli (ST 36), Neiguan (PC 6), etc. were selected in the two acupuncture groups, as well as back-shu points selected by the meridian heat sensing technique. Electroacupuncture was connected to ipsilateral Zusanli (ST 36) and Neiguan (PC 6), with continuous wave, 2 Hz in frequency for 20 min. The Edmonton symptom assessment system (ESAS) score was observed on day 1-7, 14, and 21 of each cycle of chemotherapy respectively in the 3 groups.
RESULTS:The symptom burden was worst within 7 days of each cycle of chemotherapy in the 3 groups. After the 3rd chemotherapy cycle, the total score of ESAS in the low-dose acupuncture group was lower than the control group (P<0.05), the total score and the scores of feeling of non-well being, pain and shortness of breath of ESAS in the acupuncture group (the high-dose acupuncture group combined with the low-dose acupuncture group) were lower than the control group (P<0.05).
CONCLUSION:Acupuncture shows promising effect in controlling symptom burden during adjuvant chemotherapy in gastric cancer patients after gastrectomy.
