Effect of electroacupuncture on endometrial receptivity and IVF-ET pregnancy outcomes in patients with diminished ovarian reserve.
10.13703/j.0255-2930.20210901-k0002
- Author:
Jie SHEN
1
;
You-Ling GAO
2
,
3
;
Ge LU
1
;
Li CHEN
4
;
Jie CHENG
1
;
You-Bing XIA
5
,
6
Author Information
1. School of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China.
2. School of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
3. Department of Acupuncture and Moxibustion, Yangzhou Hospital of TCM.
4. Reproductive Medicine Center, General Hospital of Eastern Theater Command of PLA.
5. First Affiliated Hospital of Nanjing Medical University, Nanjing 211166, Jiangsu Province
6. Affiliated Hospital of Xuzhou Medical University, Xuzhou 221004, Jiangsu Province.
- Publication Type:Randomized Controlled Trial
- Keywords:
diminished ovarian reserve;
electroacupuncture;
endometrial receptivity;
in vitro fertilization and embryo transfer;
pregnancy outcomes;
randomized controlled trial (RCT)
- MeSH:
Chorionic Gonadotropin;
Electroacupuncture;
Endometrium;
Female;
Fertilization in Vitro;
Humans;
Ovarian Diseases;
Ovarian Reserve;
Pregnancy;
Pregnancy Outcome;
Pregnancy Rate
- From:
Chinese Acupuncture & Moxibustion
2022;42(8):879-883
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the effect of electroacupuncture on endometrial receptivity and the pregnancy outcomes of in vitro fertilization and embryo transfer (IVF-ET) in the patients with diminished ovarian reserve (DOR).
METHODS:Sixty-eight patients of DOR undertaken IVF-ET were randomized into an observation group (34 cases, 2 cases dropped off) and a control group (34 cases, 1 case dropped off). In the control group, endometrial preparation was performed according to the routine protocol. In the observation group, on the base of the treatment as the control group, acupuncture was applied to Geshu (BL 17), Shenshu (BL 23), Mingmen (GV 4), Shiqizhui (EX-B 8), Ciliao (BL 32), Zhongliao (BL 33), Tianshu (ST 25), Qihai (CV 6) and Guanyuan (CV 4), etc. Electric stimulation was given at Ciliao (BL 32)-Zhongliao(BL 33), Tianshu (ST 25)-Zigong (EX-CA 1), with disperse-dense wave, 2 Hz/15 Hz in frequency and tolerable current in intensity. Electroacupuncture was given once every two days, 3 times weekly, lasing 3 menstrual cycles till 1 day before embryo transfer. The endometrial thickness and morphology were observed on the day of human chorionic gonadotropin (HCG) of egg retrieval cycle, the day of endometrial transformation in frozen-thawed embryo transfer (FET) cycle and the day of embryo transfer in both groups successively; as well as HCG positive rate, clinical pregnancy rate, embryo implantation rate and live birth rate.
RESULTS:In the observation group, the proportion of type A endometrium on the embryo transfer day was higher than those on HCG day of the egg retrieval cycle and the endometrial transformation day of FET cycle (P<0.05), and also higher than that of the control group (P<0.01). In the observation group, HCG positive rate, clinical pregnancy rate, embryo implantation rate and live birth rate were 75.0% (24/32), 71.9% (23/32), 47.4% (27/57) and 56.3% (18/32) respectively, and all higher than 36.4% (12/33), 30.3% (10/33), 18.0% (11/61) and 15.2% (5/33) in the control group separately (P<0.01).
CONCLUSION:Electroacupuncture improves the endometrial receptivity and IVF-ET pregnancy outcomes in the patients of diminished ovarian reserve.
