Effect of staged acupuncture on serum irisin level and neurological rehabilitation in patients with ischemic stroke.
10.13703/j.0255-2930.20210823-k0006
- Author:
Yong CHEN
1
;
Zhong-Heng DU
1
;
Hai-Yan CHEN
2
;
Yan PAN
2
Author Information
1. Department of Acupuncture, Tuina and Physical Therapy, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325100, Zhejiang Province, China.
2. School of Nursing, Wenzhou Medical University, Wenzhou 325005, Zhejiang Province.
- Publication Type:Randomized Controlled Trial
- Keywords:
irisin;
ischemic stroke;
nerve function;
rehabilitation;
staged acupuncture
- MeSH:
Acupuncture Therapy;
Fibronectins;
Humans;
Ischemic Stroke;
Muscle Spasticity;
Neurological Rehabilitation;
Paralysis/complications*;
Stroke/therapy*;
Stroke Rehabilitation;
Treatment Outcome
- From:
Chinese Acupuncture & Moxibustion
2022;42(8):857-862
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effect of staged acupuncture on serum irisin level, neurological deficit, balance ability and spasticity in patients with ischemic stroke.
METHODS:Sixty patients with ischemic stroke were randomly divided into a staged acupuncture group and a routine acupuncture group, 30 cases in each group; another 30 healthy subjects were selected as a normal group. The patients with ischemic stroke were treated with aspirin (100 mg each time, once a day, changing to 50 mg for prophylactic dose after 4 weeks). The patients in the staged acupuncture group were treated with staged acupuncture (acupoints were selected according to the soft paralysis period, spasticity period and recovery period, sequelae period) and rehabilitation treatment, while the patients in the routine acupuncture group were treated with acupuncture of soft paralysis-period as the staged acupuncture group and rehabilitation treatment. All the treatment was given once a day, 5 times a week, 2 weeks as a course of treatment, and 4 consecutive courses of treatment were provided. Before treatment and at 2 weeks, 4 weeks, 6 weeks and 8 weeks into treatment, the serum irisin level was measured, and the scores of National Institutes of Health stroke scale (NIHSS), Fugl-Meyer assessment scale-balance (FM-B) and comprehensive spasticity scale (CSS) were compared, and the correlation between the serum irisin level and NIHSS and FM-B scores in the two groups was analyzed.
RESULTS:Before treatment, the serum irisin levels in the two groups were lower than those in the normal group (P<0.01). Compared before treatment, the serum irisin levels and FM-B scores were increased (P<0.01), and the NIHSS scores were decreased at 2, 4, 6 and 8 weeks into treatment in the two groups (P<0.01). At 4, 6 and 8 weeks into treatment, in the staged acupuncture group, the serum irisin levels and FM-B scores were higher than those in the routine acupuncture group (P<0.01, P<0.05), and the NIHSS scores were lower than those in the routine acupuncture group (P<0.01). After treatment, the CSS scores in the two groups were increased first and then decreased. Compared before treatment, the CSS scores were increased at 2, 4, 6 and 8 weeks into treatment in the two groups (P<0.01). At 4, 6 and 8 weeks into treatment, the CSS scores in the staged acupuncture group were lower than those in the routine acupuncture group (P<0.01). The serum irisin level was negatively correlated with NIHSS score (r =-0.772, P =0.000), and positively correlated with FM-B score (r =0.675, P =0.000).
CONCLUSION:The severity of neurological deficit and balance ability are related to serum irisin level in patients with ischemic stroke. The staged acupuncture could increase the serum irisin level, improve the neurological function, balance ability and spasticity in patients with ischemic stroke.
