Naochang Tongtiao acupuncture based on brain-gut axis for acute ischemic stroke and its effect on levels of IL-17, hs-CRP and TMAO.
10.13703/j.0255-2930.20210821-k0004
- Author:
Hui WANG
1
,
2
;
Shou-Qing LEI
3
;
Xiao-Zheng DU
4
;
Bo YUAN
1
,
2
;
Min-Ke LIU
5
Author Information
1. Department of Acupuncture and Moxibustion, Affiliated Hospital of Gansu University of CM, Lanzhou 730030, China
2. Huangfumi Acupuncture-Moxibustion Hospital of Gansu Province, Lanzhou 730030.
3. Department of Rehabilitation and Orthopaedics, Affiliated Hospital of Gansu University of CM, Lanzhou 730030, China.
4. College of Acupuncture-Moxibustion and Tuina, Gansu University of CM.
5. Department of Neurology, Affiliated Hospital of Gansu University of CM, Lanzhou 730030, China.
- Publication Type:Randomized Controlled Trial
- Keywords:
Naochang Tongtiao acupuncture;
National Institution of Health stroke scale (NIHSS) score;
acute ischemic stroke;
hypersensitive C reactive protein (hs-CRP);
interleukin-17 (IL-17);
trimethylamine oxide (TMAO)
- MeSH:
Acupuncture Points;
Acupuncture Therapy;
Brain-Gut Axis;
C-Reactive Protein;
Humans;
Interleukin-17;
Ischemic Stroke/therapy*;
Methylamines;
Stroke/therapy*;
Treatment Outcome
- From:
Chinese Acupuncture & Moxibustion
2022;42(8):853-856
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the clinical therapeutic effect on acute ischemic stroke between Naochang Tongtiao acupuncture (acupuncture for brain-gut homology) and conventional acupuncture, and to explore the possible mechanism.
METHODS:A total of 64 patients with acute ischemic stroke were randomized into an observation group and a control group, 32 cases in each one. Basic western medical therapy was adopted in both groups. In the observation group, Naochang Tongtiao acupuncture was applied at anterior oblique line of vertex-temporal, Zhongwan (CV 12), Guanyuan (CV 4), Tianshu (ST 25), Zusanli (ST 36), Shangjuxu (ST 37) and Xiajuxu (ST 39). In the control group, conventional acupuncture was applied. The treatment was given once a day, 6 days a week for 3 weeks in both groups. Before and after treatment, National Institution of Health stroke scale (NIHSS) score, serum levels of interleukin-17 (IL-17) and hypersensitive C reactive protein (hs-CRP), and plasma level of trimethylamine oxide (TMAO) were compared in the two groups.
RESULTS:After treatment, NIHSS scores, serum levels of IL-17 and hs-CRP, and plasma levels of TMAO were decreased compared before treatment in both groups (P<0.01), and those in the observation group were lower than the control group (P<0.05).
CONCLUSION:Naochang Tongtiao acupuncture can improve the nerve function in patients with acute ischemic stroke, its therapeutic effect is superior to conventional acupuncture, the mechanism may relate to the regulation on inflammatory reaction and the level of intestinal flora metabolite.
