Electroacupuncture for acute ischemic stroke and its effect on plasma levels of IL-17 and IL-10.
10.13703/j.0255-2930.20211005-k0001
- Author:
Wen-Qian LI
1
;
Shu-Ying XU
2
;
Chun-Li ZENG
2
;
Yong-Jun PENG
2
Author Information
1. Department of TCM, First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China.
2. Department of Acupuncture-Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province.
- Publication Type:Randomized Controlled Trial
- Keywords:
activity of daily living;
acute ischemic stroke;
electroacupuncture;
interleukin-10;
interleukin-17;
nerve function
- MeSH:
Acupuncture Points;
Acupuncture Therapy/methods*;
Electroacupuncture;
Humans;
Interleukin-10;
Interleukin-17;
Ischemic Stroke/therapy*;
Stroke/therapy*
- From:
Chinese Acupuncture & Moxibustion
2022;42(8):849-852
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the clinical efficacy on acute ischemic stroke (AIS) between electroacupuncture combined with conventional western medicine therapy and simple conventional western medicine therapy and its effect on plasma levels of interleukin (IL)-17 and IL-10.
METHODS:A total of 60 patients with AIS were randomized into an observation group (30 cases, 2 cases dropped off) and a control group (30 cases, 4 cases dropped off). The control group was treated with conventional western medicine therapy i.e neuroprotection and cerebral circulation improvement. On the basis of the treatment in the control group, in the observation group, acupuncture was applied at Baihui (GV 20), Yintang (GV 24+) and Quchi (LI 11), Zusanli (ST 36), Sanyinjiao (SP 6), etc. on the affected side, Baihui (GV 20)-Yintang (GV 24+), Quchi (LI 11)-Hegu (LI 4) and Zusanli (ST 36)-Sanyinjiao (SP 6) were connected with electroacupuncture, with disperse-dense wave, 2 Hz/15 Hz in frequency, once a day for consecutive 10 days. Before and after treatment, the scores of National Institution of Health stroke scale (NIHSS) and modified Barthel index (MBI) were observed, plasma levels of IL-17 and IL-10 were detected by ELISA method.
RESULTS:After treatment, NIHSS scores were decreased while MBI scores were increased compared before treatment in both groups (P<0.01); compared with the control group, NIHSS score was decreased while MBI score was increased in the observation group (P<0.05). After treatment, IL-17 levels were decreased while IL-10 levels were increased compared before treatment in both groups (P<0.01); compared with the control group, IL-17 level was decreased while IL-10 level was increased in the observation group (P<0.05).
CONCLUSION:Electroacupuncture combined with conventional western medinice therapy can improve the nerve function and activity of daily living in patients with AIS, its clinical efficacy is superior to simple conventional western medicine therapy, the mechanism may relate to the regulation on IL-17/IL-10 imbalance.
