Effect of Bushen Decoction on Na +-K+ATPase, Ca2 +-Ca2 +ATPase and Succinate Dehydrogenase in Rats with Heart Failure
10.3969/j.issn.1006-9771.2012.06.016
- VernacularTitle:中药补肾方对心力衰竭大鼠Na+-K+ATP 酶、Ca2+-Mg2+ATP 酶和琥珀酸脱氢酶的作用研究
- Author:
Wenjing SHI
;
Hua ZHOU
;
Jingfeng RONG
;
Chunyuan YUAN
- Publication Type:Journal Article
- Keywords:
Bushen decoction, hemodynamics, Na+-K+ATPase, Ca2+-Mg2+ATPase, succinate dehydrogenase, heart failure, rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2012;18(6):544-547
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Bushen decoction on Na+-K+ATPase 、Ca2+-Mg2+ATPase and succinate dehydrogenase(SDH) in rats with heart failure. Methods 60 heart failure rats were established by ligating left anterial descending coronary artery. Theywere randomly divided into model group, sham operation group, trimetazidine group, Bushen low-dose group, Bushen middle-dose groupand Bushen high-dose group with 10 rats in each group. They were gavaged 2 weeks after modeling for 8 weeks, hemodynamic changes includingleft ventricular systolic pressure (LVSP), left ventricular diastolic pressure (LVEDP), and the maximum rate left ventricular pressurerised or decreased (±LVdp/dtmax) were recorded as well as the level of Na+-K+ATP ase、Ca2+-Mg2+ATPase and SDH through the spectrophotometer.Results Compared with the sham operation group, the LVSP and + LVdp/dtmax of rats in model group decreased (P<0.05), LVEDPand -LVdp/dtmax increased (P<0.05). After Bushen intervention, contractility and diastolic function of myocardial of rats in middle and highdose group were better than model group (P<0.01), especially in high dose group.
Na+-K+ATP ase、Ca2+-Mg2+ATPase and SDH activity werehigher in Bushen groups than the model group, but lower than the sham operation group. With the increase of the doses, Na+-K+ATP ase、Ca2+-Mg2+ATPase and SDH activity gradually increased. Conclusion Bushen decoction can improve the cardiac function of rats with heartfailure that may be associated with Na+-K+ATPase, Ca2+-Mg2+ATPase and SDH activity.
