Comparison and selection of animal models of pancreatic cancer
10.3969/j.issn.1001-5256.2022.12.044
- VernacularTitle:胰腺癌动物模型的比较与选择
- Author:
Zhangli YAN
1
;
Xiaofan XU
1
;
Jiaqi XIN
2
;
Hong ZHANG
1
,
3
Author Information
1. School of Basic Medicine, Shaanxi University of Chinese Medicine, Xixian NewArea, Shaanxi 712046, China
2. Department of Gastroenterology, Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany
3. Shaanxi International Joint Research Center for Prevention and Treatment of Immune Inflammation Related Diseases with TCM, Xixian New Hrea, Shaanxi 712046, China
- Publication Type:Reviews
- Keywords:
Pancreatic Neoplasms;
Disease Models, Animal;
Chemistry, Pharmaceutical;
Xenograft Model Antitumor Assays
- From:
Journal of Clinical Hepatology
2022;38(12):2908-2912
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer (PC) has the characteristics of insidious onset, rapid progression, and poor prognosis. Up to now, there are no standard clinical regimens for the treatment of PC, and the benefit rate of new targeted therapy remains at a relatively low level, which results in the high mortality rate of PC. Therefore, an understanding of the development and progression mechanisms for PC has become a difficult issue to be solved, and establishment of reliable animal models for PC is the basis for exploring the development, progression, invasion, and metastasis of PC and the optimization of effective therapeutic targets. At present, a large number of studies have established various animal models for PC, and this article compares the commonly used animal models to provide a reference for the selection of animal models in PC research.
