Research advances in the mechanism of metabolic communication between peripheral nerves and pancreatic cancer cells
10.3969/j.issn.1001-5256.2022.12.040
- VernacularTitle:周围神经与胰腺癌细胞之间的代谢交流机制
- Author:
Gengzhou TIAN
1
,
2
,
3
,
4
;
Lei ZOU
1
,
2
,
3
,
4
Author Information
1. NHC Key Laboratory of Drug Addiction Medicine
2. Experimental Research Center of The First Affiliated Hospital of Kunming Medical University
3. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University
4. Kunming Medical University, Kunming 650032, China
- Publication Type:Reviews
- Keywords:
Pancreatic Neoplasms;
Peripheral Nerves;
Metabolic Networks and Pathways;
Neoplasm Invasiveness
- From:
Journal of Clinical Hepatology
2022;38(12):2887-2891
- CountryChina
- Language:Chinese
-
Abstract:
The metabolism of various substances is interconnected in tumor microenvironment, and the interaction of metabolic signaling pathways forms a complex metabolic network, which together maintains the homeostasis of tumor microenvironment. Peripheral nerves, which consist of the nerve trunks, plexus, ganglia, and terminals formed by perikaryons and nerve fibers, play a key role in the progression of pancreatic cancer. At present, there are relatively few studies on the mechanism of metabolic communication between peripheral nerves and pancreatic cancer cells. This article reviews recent studies and summarizes the role of amino acids, neurotransmitters, and neurotrophic factors in the progression of pancreatic cancer from the perspectives of peripheral nerves and pancreatic cancer cells, and it is believed that discussion of the mechanism of metabolic communication between peripheral nerves and pancreatic cancer cells may help to discover new targets for pancreatic cancer treatment.
