Macrophage depletion and its application in liver injury
10.3969/j.issn.1001-5256.2022.12.034
- VernacularTitle:巨噬细胞耗竭及其在肝损伤中的应用
- Author:
Qian YU
1
;
Sai ZHAO
1
;
Liangming LIU
1
Author Information
1. Songjiang Hospital Affiliated to Nanjing Medical University, Shanghai 201615, China
- Publication Type:Reviews
- Keywords:
Kupffer Cells;
Macrophage;
Liver Injury
- From:
Journal of Clinical Hepatology
2022;38(12):2859-2863
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages are a heterogeneous cell population involved in tissue homeostasis, inflammation, and various pathophysiological processes. Selective clearance of macrophages in vivo is a widely accepted method used to investigate whether macrophages are involved in any specific biological regulatory mechanism. Understanding the different methods and principles of macrophage depletion helps explore appropriate modeling solutions to investigate the relationship between macrophages and diseases. Hepatic macrophages play a crucial role in hepatotoxicity. This article reviews the methods of macrophage depletion and the regulatory role of macrophage depletion in liver injury and repair.
