Advances in the mechanism of action of silent information regulator 1 in alcoholic liver disease and related pharmaceutical studies
10.3969/j.issn.1001-5256.2022.12.030
- VernacularTitle:沉默调节蛋白1在酒精性肝病中的作用机制及相关药物研究进展
- Author:
Tiantian LIU
1
;
Jiangkai LIU
2
;
Suling LI
2
;
Liang LIU
1
;
Yaru ZHANG
1
;
Jianwen ZHANG
1
;
Bingqian LI
1
Author Information
1. The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450018, China
2. Spleen, Stomach and Hepatobiliary Department, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
- Publication Type:Reviews
- Keywords:
Alcoholic Liver Disease;
Silent Information Regulator Proteins;
Inflammation
- From:
Journal of Clinical Hepatology
2022;38(12):2841-2845
- CountryChina
- Language:Chinese
-
Abstract:
Alcoholic liver disease (ALD) is one of the main chronic liver diseases in the world, and the prevalence rate of ALD is increasing year by year in China, with a trend of earlier age of onset. Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase and plays a significant role in cell metabolism, oxidative stress, and inflammation, and it is expected to become a new therapeutic target for ALD. This article reviews the mechanism of action of SIRT1 in ALD and related pharmaceutical studies, in order to provide a reference and strategies for further research on the pathogenesis of ALD and its potential therapeutic targets.
