Protective mechanism of interleukin-10 against nonalcoholic fatty liver disease and its prospect in treatment
10.3969/j.issn.1001-5256.2022.12.029
- VernacularTitle:IL-10对非酒精性脂肪性肝病发病的保护机制及其治疗前景
- Author:
Ruifeng LI
1
;
Tingni ZONG
1
;
Guangrong DAI
1
Author Information
1. Department of Gastroenterology, Yan'an University Affiliated Hospital, Yan'an, Shaanxi 716000, China
- Publication Type:Reviews
- Keywords:
Non-Alcoholic Fatty Liver Disease;
Interleukin-10;
Therapeutics
- From:
Journal of Clinical Hepatology
2022;38(12):2836-2840
- CountryChina
- Language:Chinese
-
Abstract:
With the prevalence of obesity and metabolic syndrome, nonalcoholic fatty liver disease (NAFLD) has become the largest chronic liver disease in China. However, the pathogenesis of NAFLD remains unclear, and recent studies have found that interleukin-10 (IL-10) not only plays an important role in the pathogenesis of autoimmune diseases, inflammatory diseases, and malignant tumors, but also plays a key regulatory role in the pathogenesis of NAFLD. This article reviews the protective mechanism of IL-10 against NAFLD and its prospect in treatment, so as to further explore the clinical value of IL-10 in the diagnosis and treatment of NAFLD.
