Association of fat mass- and obesity-associated gene (FTO) polymorphisms with susceptibility to nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2022.12.009
- VernacularTitle:脂肪量和肥胖相关基因多态性与非酒精性脂肪性肝病易感性的关系
- Author:
Lei MA
1
;
Anhua HAO
1
;
Xinxin HU
1
;
Zhenzhen ZHAO
2
;
Lin ZHOU
1
;
Yongning XIN
3
Author Information
1. Department of Infectious Diseases, Qingdao Chengyang District People's Hospital, Qingdao, Shandong 266109, China
2. Clinical Research Center, Qingdao Municipal Hospital affiliated to Qingdao University, Qingdao, Shandong 266071, China
3. Department of Infectious Diseases, Qingdao Municipal Hospital affiliated to Qingdao University, Qingdao, Shandong 266071, China
- Publication Type:Original Articles_Fatty Liver Diseases
- Keywords:
Non-alcoholic Fatty Liver Disease;
Genome;
Polymorphism, Single Nucleotide
- From:
Journal of Clinical Hepatology
2022;38(12):2723-2727
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between Fat Mass- and obesity-associated gene (FTO) polymorphisms and the susceptibility of non-alcohol-related fatty liver disease (NAFLD) in a Han population from Qingdao region of China. Methods A total of 119 NAFLD patients were recruited from Qingdao Municipal Hospital and Chengyang District People's Hospital and 187 control individuals who received annual physical examination were also included. Their clinicopathological information and study questionnaire were collected. Their fasting venous blood was extracted for biochemical analyses and FTO polymorphism genotyping using the polymerase chain reaction combined with DNA sequencing. The data were statistically assessed. Results The data showed statistically significant differences in age, BMI, ALT, GGT, TG and Bil between NAFLD patients and normal controls (all P < 0.05). FTO polymorphism genotyping data showed three genotypes of FTO rs1421085 (TT, CT, and CC), rs8050136 (TT, CT, and CC) and rs9939609 (TT, AT, AA). However, there was no statistical difference in both allele frequency and genotype of FTO rs1421085, rs9939609, and rs8050136 between NAFLD and controls (all P > 0.05) and there was also no statistical difference in clinical parameters among these genotype carriers (all P > 0.05). Conclusion NAFLD patients showed significantly statistical differences in age, BMI, ALT, GGT, TG, and BIL vs. those of normal controls. However, this study did not find any association of FTO rs1421085, rs9939609, and rs8050136 polymorphisms with NAFLD susceptibility in this Qingdao region of Han Chinese population.
