Different Effects of Venlafaxine and Paroxetine on Comorbidity of Anxiety and Depression

VernacularTitle:文拉法辛缓释胶囊与帕罗西汀治疗抑郁和焦虑共病的疗效比较
Author: Haihang YU ; Haiyun ZHONG ; Tanglong LIU
Publication Type:Journal Article
Keywords: venlafaxine, paroxetine, depression, anxiety, comorbidity
From: Chinese Journal of Rehabilitation Theory and Practice 2012;18(5):470-471
CountryChina
Language:Chinese
Abstract: Objective To compare the efficacy and safety of venlafaxine and paroxetine in the treatment of comorbidity of depressionwith anxiety disorder. Methods 86 cases simultaneously conformed to depression and anxiety disorder accepted venlafaxine (group A) orparoxetine (group B) for 8 weeks. They were assessed with Hamilton Rating Scale for Depression (HAMD) and Hamilton Rating Scale forAnxiety (HAMA) before and 1, 2, 8 weeks after treatment. Results There was no significant difference in the scores of HAMD and HAMAbetween both groups before treatment, and there was since 1 week after treatment (P<0.05). 45.4% were clinically cured and 75.0% improvedin group A, which was 33.3% and 66.6% in group B 8 weeks after treatment (P<0.05). Conclusion Venlafaxine is more efficaciousthan paroxetine on anxiety and depression comorbidity.