Expression of Brain-derived Neurotrophic Factor in Temporal Cortex of Autism Model Rats

VernacularTitle:脑源性神经营养因子在孤独症模型鼠颞叶皮层中的表达
Author: Shujuan CHEN ; Zhimei JIANG ; Lanmin GUO ; Shiling ZHANG ; Qifeng SUN ; Li LI ; Changshan WANG
Publication Type:Journal Article
Keywords: autism, brain-derived neurotrophic factor, sodium valproate, rats
From: Chinese Journal of Rehabilitation Theory and Practice 2012;18(5):426-429
CountryChina
Language:Chinese
Abstract: Objective To explore the role of brain-derived neurotrophic factor (BDNF) in pathogenesis of autism. Methods 12.5 d pregnantWistar rats were injected sodium valproate (VPA) 600 mg/kg or normal saline (NS). Their newborn rats were observed ethologically.The expression of BDNF was measured in their temporal cortex with immunohistochemical stain. Results Compared with NS group, VPAgroup expressed less body mass (P<0.05), eyes opening delay (P<0.05), poorer coordination response (P<0.05), slower taxis response (P<0.05). The number of social behavior decreased (P<0.05), latency increased (P<0.05), duration shortened (P<0.05), repetitive activities increased(P<0.05). Purkinje cells reduced in cerebellum. The expression of BDNF increased significantly in temporal cortex 1 d, 7 d and 14 dpostnatally (P<0.01), but decreased 35 d and 49 d postnatally (P<0.01). Conclusion BDNF plays a role in the pathogenesis of autism.