Effect of Body Weight Support Treadmill Training and Electroacupuncture on Expression of Brain-derived Neurotrophic Factor inSpinal Cord Injuried Rats

VernacularTitle:减重步行训练结合电针对脊髓损伤大鼠损伤组织脑源性神经营养因子的影响
Author: Shuai LIU ; Yanli XING ; Wei MENG
Publication Type:Journal Article
Keywords: spinal cord injury, electroacupuncture, body weight support treadmill training, brain-derived neurotrophic factor, rats
From: Chinese Journal of Rehabilitation Theory and Practice 2012;18(5):420-422
CountryChina
Language:Chinese
Abstract: Objective To investigate the mechanism of body weight support treadmill training (BWSTT) and electroacupuncture (EA)for spinal cord injury. Methods 56 adult SD rats were divided into control group (n=16), EA group (n=16), BWSTT-EA group (n=16) andblank group (n=8). They were treated 3 d after operation, and assessed with Basso-Beattie-Bresnahan (BBB) scale and the brain-derived neurotrophicfactor (BDNF) was measured in injured tissue with real time immunohistochemisty assay 1 d, 7 d, 14 d, 21 d after treatment. ResultsThe score of BBB was significantly higher in the BWSTT- EA group than in control group and EA group 1 d, 7 d, 14 d, 21 d after treatment(P<0.05), as well as the expression of BDNF (P<0.05). Conclusion BWSTT and EA can promote the recovery of spinal cord injury,which may associate with the expression of BDNF in injured tissue.