Effect of Ultrashort Wave Diathermy on Expression of Tumor Necrosis Factor-α and Bcl-2 after Cerebral Ischemia/Reperfusion inRats

VernacularTitle:超短波对大鼠脑缺血再灌注后肿瘤坏死因子-α和Bcl-2 表达的影响
Author: Xiongang HUANG ; Xiangming YE ; Jian LIN ; Xiaolin LIU ; Lin LI
Publication Type:Journal Article
Keywords: cerebral ischemia, ischemia/reperfusion, ultrashort wave diathermy, tumor necrosis factor, Bcl-2
From: Chinese Journal of Rehabilitation Theory and Practice 2012;18(5):411-413
CountryChina
Language:Chinese
Abstract: Objective To observe the effects of ultrashort wave diathermy on the expression of tumor necrosis factor-α (TNF-α) andBcl-2 in hippocampus, striatum and motor cortex of rats with cerebral ischemia/reperfusion. Methods The model of focal ischemia/reperfusionin Sprague-Dawley rats was induced with intraluminal middle cerebral artery occlusion (MCAO) with nylon monofilament suture. Therats were divided into 3 groups: sham group (n=6), model group (n=6) and ultrashort wave diathermy group (n=6). Brain tissue slices wereimmunohistochemically stained (SABC) to observe the expression of TNF-α and Bcl-2. Results The expression of TNF-α and Bcl-2 in lefthippocampus, striatum and motor cortex was higher in the model group than in the sham group (P<0.01). The expression of TNF-α was lowerbut Bcl-2 was higher in the ultrashort wave diathermy group than in the model group (P<0.05). Conclusion Ultrashort wave diathermycan affect the expression of TNF-α and Bcl-2, which may associate to the neuroprotection from focal cerebral ischemia/reperfusion injury.