Relationship between Promoter Polymorphism-438 A/G of Thrombin-activatable Fibrinolysis Inhibitor Gene and Cerebral Infarction

VernacularTitle:凝血酶激活纤溶抑制物基因启动子区-438A/G多态性与脑梗死的关系
Author: Yusen CHEN ; Zhiliang ZENG ; Zhijun LIN ; Wenchuan XIAN ; Wangtao ZHONG ; Bin ZHAO ; Zhien XU
Publication Type:Journal Article
Keywords: thrombin-activatable fibrinolysis inhibitor, promoter, polymorphism, atherosclerosis, cerebral infarction.
From: Chinese Journal of Rehabilitation Theory and Practice 2012;18(5):406-408
CountryChina
Language:Chinese
Abstract: Abstract: Objective To research the relationship between promoter polymorphism-438 A/G of thrombin-activatable fibrinolysis inhibitorgene (TAFI-438 A/G) and atherosclerotic cerebral infarction (ACI) in Chinese Han population. Methods TAFI-438A/G genotypes andtheir allele frequencies were identified with the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) in225 ACI patients and 184 healthy controls. Results There was no significant difference of TAFI-438A/G polymorphism between ACI groupand control group. Stratified by gender, in males, the incidence of A allele was 28.6% in ACI group, and 20.6% in control (P=0.039); of theAA genotype was 9.0% in ACI group, and 1.9% in control (P=0.019). But no significant difference was found in females. ConclusionTAFI-438A/G polymorphism is associated with the risk of ACI in males, that AA genotype may increase the risk of ACI.