Nonhuman Primate Chronic Stroke Model with Middle Cerebral Artery Endovascular Embolism
10.3969/j.issn.1006-9771.2015.01.001
- VernacularTitle:血管内栓塞大脑中动脉制作非人灵长类卒中慢性期模型的研究
- Author:
Qiang WANG
;
Tong ZHANG
;
Chunyu ZHAO
;
Jianmin XU
;
Mei WEN
;
Zhisheng FEI
- Publication Type:Journal Article
- Keywords:
cerebral infarction, chronic stage, nonhuman primate, animal model, endovascular embolism
- From:
Chinese Journal of Rehabilitation Theory and Practice
2012;18(5):401-405
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish chronic cerebral infarction animal model in nonhuman primate. Methods 10 adult male rhesus monkeyswere embolized the middle cerebral artery (MCA) in contra-lateral of handedness, and divided into M1 segment embolism group (n=3), upper trunk embolism group (n=5), and lower trunk embolism group (n=2). Acute neurological deficit was evaluated with standard neurologicalscale, and the motor function in chronic stage was assessed with a task of retrieving food pill in wells. Results Animals in M1 segmentembolism group all died 38~62 h after surgery. Upper trunk embolism group survived, and MRI showed front parietal cortex infarctioncontra-lateral paralyzed side. All of them paralyzed one side in acute stage, and 4 of them persisted dysfunction in chronic stage, that couldnot finish the task of retrieving food pill in wells; only one completed the task. The lower trunk embolism group paralyzed one side in acutestage, but recovered quickly and completely, that finished the task within 7 d. Conclusion Embolism of MCA upper trunk can cause infarctionof precise and proper size with one side limb dysfunction in the acute stage and long-term dysfunction in most animals, which is feasiblefor treatment and neural plasticity research in recovery.
