Loss of Perivascular Aquaporin 4 and Inwardly Rectifying Potassium Channel 4.1 in Human Mesial Temporal Lobe Epilepsy

VernacularTitle:人颞叶内侧癫痫海马组织星形胶质细胞水通道蛋白4 和内向整流性钾离子通道4.1 的再分布
Author: Qian XU ; Zhenrong SUN ; Guilin LI ; Yilin SUN ; Shaohua YANG ; Fang YUAN
Publication Type:Journal Article
Keywords: mesial temporal lobe epilepsy, aquaporin 4, inwardly rectifying potassium channel 4.1
From: Chinese Journal of Rehabilitation Theory and Practice 2012;18(3):215-218
CountryChina
Language:Chinese
Abstract: Objective To investigate the distribution of aquaporin 4 (AQP4) and inwardly rectifying potassium channel 4.1 (Kir4.1) inthe astrocytes from human mesial temporal lobe epilepsy (MTLE). Methods Hippocampal specimens, including 10 cases of MTLE and 6cases of non-MTLE, were observed under optical and transmission electron microscopy. The distribution of AQP4 and Kir4.1 in astrocyteswas investigated with immunoflurescence. Results Compared with non-MTLE hippocampus, the main structural changes of MTLE includedremarkable hyperplasia astrocytes, serious swelling astrocytes and distinguished astrophy neurons. In non-MTLE hippocampus, immunoflurescencesignals of AQP4 and Kir4.1 were enriched along perivascular astrocyte end-feet domain. However, it reveals significant loss ofAQP4 and Kir4.1 in perivascular astrocyte end-feet domain in MTLE. Conclusion Loss of perivascular AQP4 and Kir4.1 in the humanMTLE may help to understand the roles of astrocyte in MTLE.