Clinical characteristics of patients with COVID-19 vaccine-related pneumonitis: a case series and literature review
- Author:
Ji Young PARK
1
;
Joo-Hee KIM
;
Sunghoon PARK
;
Yong Il HWANG
;
Hwan Il KIM
;
Seung Hun JANG
;
Ki-Suck JUNG
;
Yong Kyun KIM
;
Hyun Ah KIM
;
In Jae LEE
Author Information
- Publication Type:2
- From:The Korean Journal of Internal Medicine 2022;37(5):989-1001
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background/Aims:Pulmonary toxicities of coronavirus disease 2019 (COVID-19) vaccination are exceedingly rare. However, there are a few reported cases after mRNA vaccination, especially from Asian countries. The purpose of this study was to report the clinical characteristics of patients with COVID-19 vaccine-related pneumonitis (CV-P) and to review cases reported in the literature.
Methods:We performed a prospective, observational case series analysis.
Results:Eleven patients with a median age of 80 years were enrolled. Ten patients developed CV-P after BNT162b2-mRNA vaccination and one after ChAdOx1 nCoV-19 vaccination. We identified various patterns of CV-P, including transient infiltration, life-threatening acute respiratory distress syndrome, and aggravation of underlying interstitial lung disease. Most patients showed favorable outcomes with good responses to corticosteroid therapy.
Conclusions:Identifying the mechanism of CV-P requires further investigation; however, radiological and laboratory findings in our case series support inflammatory dysregulation in the lung parenchyma after vaccination. Clinicians should consider CV-P in patients with atypical lung infiltration, no specific etiologies, and recent COVID-19 vaccination
