Alteration of Th1 and Th17 Inflammatory Cytokines in the Skin Lesions after Psoriasis Treatment
- Author:
Hyo Jin PARK
1
;
Hyun Joon CHANG
;
Tae Geun KIM
;
Mi Yeon KWON
;
Chae Yoon LIM
;
Hyun Jeong JU
;
Kyung Ho LEE
;
Chul Jong PARK
Author Information
1. Department of Dermatology, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea
- Publication Type:Original Article
- From:Korean Journal of Dermatology
2022;60(7):409-413
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Psoriasis is a T cell-mediated disorder. Appropriate treatment of psoriasis can result in a plethora of dynamic changes in the T cells and their cytokine production. Studies on the expression of Th1 and Th17 inflammatory cytokines after various treatments have reported inconsistent results.
Objective:This study aimed to investigate the changes in inflammatory cytokine expression in psoriasis skin lesions before and after psoriasis treatment.
Methods:Five patients with plaque psoriasis were enrolled in the study. The tissue mRNA and protein levels of interleukin (IL)-12, IL-2, interferon (IFN)-γ, IL-23, IL-17A, and IL-22 in psoriatic skin lesions before and after psoriasis treatment were detected using real-time polymerase chain reaction and immunohistochemical staining, respectively.
Results:The decrease in the psoriasis area and severity index was accompanied by a reduction in IL-12 and IL-23 mRNA levels and a concomitant reduction of IL-2 and IL-17A protein levels in psoriasis skin lesions. Both mRNA and protein levels of IFN-γ in psoriatic skin lesions increased after treatment.
Conclusion:The mRNA levels of tissue inflammatory cytokines (IL-12 and IL-23) and the protein levels of tissue inflammatory cytokines (IL-2 and IL-17A) significantly decreased after psoriasis treatment. The mRNA and protein levels of IFN-γ increased, even after psoriasis treatment.
