Effect of post-treatment fluvastatin for hemorrhagic shock in rats
- Author:
Oh Hyun KIM
1
;
Soo-Ki KIM
;
Soon-Hee JUNG
;
Sung Oh HWANG
;
Hyun KIM
;
KyoungChul CHA
;
Yong Sung CHA
;
Gyo Jin AN
;
Kang Hyun LEE
Author Information
1. Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea
- Publication Type:Original Article
- From:Journal of the Korean Society of Emergency Medicine
2022;33(5):506-515
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:This study aimed to investigate the biochemical, histologic, and immunologic effects of post-treatment administration of fluvastatin in a hemorrhagic shock (HS) rat model.
Methods:Experimental rats were randomly divided into four groups: control group: no drugs and did not undergo HS; control statin group: fluvastatin 1 mg/kg (no HS); HS group: normal saline after HS; HS+statin group: fluvastatin 1 mg/kg+normal saline after HS. Briefly, HS was induced by femoral arterial catheter blood extraction of 30% of the total blood volume. The mean arterial pressure and heart rate were monitored for 2 hours after starting blood withdrawal. Arterial blood gas, complete blood count, and serum cytokine levels were measured at baseline, 2 hours after HS, and 48 hours after resuscitation. The kidneys, lungs, and small intestines were removed for pathological examination 48 hours after HS.
Results:At the end of the resuscitation period, the HS and HS+statin groups showed reduced bicarbonate, base excess, and platelet counts, all of which differed significantly from values in the control and control+statin groups. Compared to the control group, the HS+statin group exhibited significantly elevated serum interleukin-10 (IL-10) at 2 hours after resuscitation (P<0.05). Except for IL-10, the group-time interaction was not significant for other cytokine profiles.
Conclusion:This study demonstrates that post-treatment with fluvastatin after HS increases the production of the anti-inflammatory cytokine IL-10 and affects the cytokine profiles in rats.
