Clinical Factors Related to Change of Depression Severity in Major Depressive Disorder Through Index Electroconvulsive Therapy
- Author:
Jae-Won YANG
1
;
Yang Tae KIM
;
Hee Cheol KIM
;
Sung-Won JUNG
;
Hojun LEE
Author Information
1. Department of Psychiatry, Keimyung University School of Medicine, Daegu, Korea
- Publication Type:Original Articles
- From:
Journal of the Korean Society of Biological Therapies in Psychiatry
2022;28(3):98-108
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objectives:：The aim of this study was to investigate the factors associated with changes in depression severity in index electroconvulsive therapy (ECT) for major depressive disorder.
Methods:：A retrospective analysis was performed on 80 patients with major depressive disorder who received index ECT. The severity of depression was assessed using the Hamilton depression rating scale-17 (HDRS-17). Multiple linear regression analysis and logistic regression analysis were performed to identify the factors associated with the change of depression severity and the predictors of the 50% or greater reduction rate of HDRS-17.
Results:：55 (68.8%) patients were HDRS-17 score change ≥50% group, and 25 (31.2%) patients were HDRS-17 score change <50% group. HDRS-17 score change ≥50% group had a shorter episode duration before ECT (11.91±8.63 vs 17.68±11.15 weeks, p=0.027) and more ECT sessions (8.60±2.91 vs 6.80±3.34 sessions, p=0.017). The higher baseline score of anxiety (B=0.937, β=0.374, p<0.001), depression (B=0.846, β=0,324, p=0.001), and somatic symptom (B=0.995, β=0.210, p=0.031) dimensions was associated with the change of HDRS-17 score from baseline. The longer episode duration until the start of ECT was associated with lower likelihood of HDRS-17 score change ≥50% (Wald χ2 =7.74, OR=1.08, 95% CI: 1.02-1.14, p=0.005). The greater number of ECT sessions predicted the HDRS-17 score change ≥50% (Wald χ2 =7.85, OR=0.75, 95% CI=0.62-0.92, p=0.005) Conclusions：In higher baseline anxiety, depression, and somatic symptoms severity, implementing sufficient sessions of ECT in pharmacological treatment phase of relatively shorter duration of major depressive episode may help reduce HDRS-17 score.
