Movement Disorders Resulting From Bilateral Basal Ganglia Lesions in End-Stage Kidney Disease: A Systematic Review
- Author:
Kah Hui YAP
1
;
Nurul Husna BAHARUDIN
;
Abdul Halim Abdul GAFOR
;
Rabani REMLI
;
Shen-Yang LIM
;
Wan Asyraf Wan ZAIDI
;
Shahrul AZMIN
;
Shahizon Azura Mohamed MUKARI
;
Raihanah Abdul KHALID
;
Norlinah Mohamed IBRAHIM
Author Information
- Publication Type:12
- From:Journal of Movement Disorders 2022;15(3):258-263
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:The basal ganglia (BG) are susceptible to fluctuations in blood urea levels, sometimes resulting in movement disorders. We described patients with end-stage kidney disease (ESKD) presenting with movement disorders associated with bilateral BG lesions on imaging.
Methods:We report four patients and systematically reviewed all published cases of ESKD presenting with movement disorders and bilateral BG lesions (EBSCOhost and Ovid).
Results:Of the 72 patients identified, 55 (76.4%) were on regular dialysis. Parkinsonism was the most common movement disorder (n = 39; 54.2%), followed by chorea (n = 24; 33.3%). Diabetes mellitus (n = 51; 70.8%) and hypertension (n = 16; 22.2%) were the most common risk factors. Forty-three (59.7%) were of Asian ethnicity. Complete clinical resolution was reported in 17 (30.9%) patients, while 38 (69.1%) had incomplete clinical resolution with relapse. Complete radiological resolution occurred in 14 (34.1%) patients.
Conclusion:Movement disorders associated with BG lesions should be recognized as a rare and potentially reversible metabolic movement disorder in patients with ESKD.
