Sensitivity of Detecting Alpha-Synuclein Accumulation in the Gastrointestinal Tract and Tissue Volume Examined
- Author:
Chaewon SHIN
1
;
Seong-Ik KIM
;
Sung-Hye PARK
;
Jung Hwan SHIN
;
Chan Young LEE
;
Han-Kwang YANG
;
Hyuk-Joon LEE
;
Seong-Ho KONG
;
Yun-Suhk SUH
;
Han-Joon KIM
;
Beomseok JEON
Author Information
- Publication Type:12
- From:Journal of Movement Disorders 2022;15(3):264-268
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:This study aimed to evaluate whether a larger tissue volume increases the sensitivity of detecting alpha-synuclein (AS) pathology in the gastrointestinal (GI) tract.
Methods:Nine patients with Parkinson’s disease (PD) or idiopathic rapid eye movement sleep disorder (iRBD) who underwent GI operation and had full-depth intestinal blocks were included. All patients were selected from our previous study population. A total of 10 slides (5 serial sections from the proximal and distal blocks) per patient were analyzed.
Results:In previous studies, pathologic evaluation revealed phosphorylated AS (+) in 5/9 patients (55.6%) and in 1/5 controls (20.0%); in this extensive examination, this increased to 8/9 patients (88.9%) but remained the same in controls (20.0%). The severity and distribution of positive findings were similar between patients with iRBD and PD.
Conclusion:Examining a large tissue volume increased the sensitivity of detecting AS accumulation in the GI tract.
