A Case of Vanishing Bile Duct Syndrome Associated with Hypersensitivity to Allopurinol.
- Author:
Seong Ho CHOI
1
;
Soo Hyun YANG
;
Young Bong SONG
;
Hye Jin KIM
;
Yeoung Tae SEO
;
Dong Seog CHOI
;
Kyoung Hyoub MOON
;
Jong Hoon BYUN
;
Eun Sil YU
Author Information
1. Department of Internal Medicine, Veterans Hospital, Seoul, Korea. ysh33@e-bohun.or.kr
- Publication Type:Case Reports ; English Abstract
- Keywords:
Allopurinol;
Vanishing bile duct syndrome;
Allopurinol hypersensitivity
- MeSH:
Allopurinol/*adverse effects;
Bile Duct Diseases/*etiology/pathology;
Drug Hypersensitivity/*complications;
English Abstract;
Gout Suppressants/*adverse effects;
Humans;
Male;
Middle Aged
- From:The Korean Journal of Hepatology
2005;11(1):80-85
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Allopurinol is frequently used for the treatment of hyperuricemia and gout. Sometimes, a life-threatening reaction develops, as is illustrated by the following case report. We describe a 60-year-old male patient who was treated with allopurinol because of asymptomatic hyperuricemia, and he was presented with fever, skin rash, eosinophilia, worsening renal function and vanishing bile duct syndrome. In this report, we discussed vanishing bile duct syndrome as a serious side effect of allopurinol, and we briefly reviewed the etiology, prevention, and treatment modalities for vanishing bile duct syndrome.