Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea
10.3346/jkms.2022.37.e297
- Author:
Youseung CHUNG
1
;
Eun Jin KIM
;
Hee-Sung KIM
;
Kyung-Hwa PARK
;
Ji Hyeon BAEK
;
Jungok KIM
;
Ji Yeon LEE
;
Chang-Seop LEE
;
Seungjin LIM
;
Shin-Woo KIM
;
Eu Suk KIM
;
Hye Jin SHI
;
Shin Hee HONG
;
Jae-Bum JUN
;
Kyung-Wook HONG
;
Jae-Phil CHOI
;
Jinyeong KIM
;
Kyung Sook YANG
;
Young Kyung YOON
Author Information
1. Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
- Publication Type:Original Article
- From:Journal of Korean Medical Science
2022;37(41):e297-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:This study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) and identify the predictors associated with the severity of COVID-19.
Methods:This multicenter observational study included consecutive pregnant women admitted because of COVID-19 confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) test at 15 hospitals in the Republic of Korea between January 2020 and December 2021.
Results:A total of 257 women with COVID-19 and 62 newborns were included in this study. Most of the patients developed this disease during the third trimester. Nine patients (7.4%) developed pregnancy-related complications. All pregnant women received inpatient treatment, of whom 9 (3.5%) required intensive care, but none of them died. The gestational age at COVID-19 diagnosis (odds ratio [OR], 1.096, 95% confidence interval [CI], 1.04–1.15) and parity (OR, 1.703, 95% CI, 1.13–2.57) were identified as significant risk factors of severe diseases. Among women who delivered, 78.5% underwent cesarean section. Preterm birth (38.5%), premature rupture of membranes (7.7%), and miscarriage (4.6%) occurred, but there was no stillbirth or neonatal death. The RT-PCR test of newborns’ amniotic fluid and umbilical cord blood samples was negative for severe acute respiratory syndrome coronavirus 2.
Conclusion:At the time of COVID-19 diagnosis, gestational age and parity of pregnant women were the risk factors of disease severity. Vertical transmission of COVID-19 was not observed, and maternal severity did not significantly affect the neonatal prognosis.
