Role of Post-translational Modification of Silent Mating Type Information Regulator 2 Homolog 1 in Cancer and Other Disorders
10.15430/JCP.2022.27.3.157
- Author:
Yeon-Hwa LEE
1
;
Su-Jung KIM
;
Young-Joon SURH
Author Information
1. Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul, Korea
- Publication Type:Review
- From:Journal of Cancer Prevention
2022;27(3):157-169
- CountryRepublic of Korea
- Language:English
-
Abstract:
Silent mating type information regulator 2 homolog 1 (SIRT1), an NAD + -dependent histone/protein deacetylase, has multifarious physiological roles in development, metabolic regulation, and stress response. Thus, its abnormal expression or malfunction is implicated in pathogenesis of various diseases. SIRT1 undergoes post-translational modifications, including phosphorylation, oxidation/reduction, carbonylation, nitrosylation, glycosylation, ubiquitination/deubiquitination, SUMOylation etc. which can modulate its catalytic activity, stability, subcellular localization, and also binding affinity for substrate proteins. This short review highlights the regulation of SIRT1 post-translational modifications and their pathophysiologic implications.
