An elevated value of C-reactive protein is the only predictive factor of restenosis after percutaneous coronary intervention.
- Author:
Woo Kon JEONG
1
;
Myung Ho JEONG
;
Kye Hun KIM
;
Sang Rok LEE
;
Ok Young PARK
;
Ju Hyup YUM
;
Won KIM
;
Ju Han KIM
;
Jae Young RHEW
;
Youn Keun AHN
;
Jeong Gwan CHO
;
Byoung Hee AHN
;
Soon Pal SUH
;
Jong Chun PARK
;
Sang Hyung KIM
;
Jung Chaee KANG
Author Information
1. The Heart Center, Chonnam National University Hospital, Kwangju, Korea.
- Publication Type:Original Article
- Keywords:
Coronary Artery Disease;
Restenosis;
C-Reactive Protein;
Percutaneous Coronary Intervention
- MeSH:
C-Reactive Protein*;
Cardiovascular Diseases;
Coronary Artery Disease;
Follow-Up Studies;
Humans;
Immunoglobulin G;
Inflammation;
Jeollanam-do;
Logistic Models;
Percutaneous Coronary Intervention*;
Pneumonia;
Prospective Studies
- From:Korean Journal of Medicine
2002;62(4):405-414
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Current techniques of percutaneous coronary interventions (PCI) remain limited by the restenosis. Recent studies provide evidence that inflammation plays a role in the pathogenesis of cardiovascular disease. METHODS: We prospectively tested whether inflammatory markers are predictors of subsequent restenosis in 272 consecutive patients with angiographically proved coronary artery disease. The patients who underwent PCI at Chonnam National University Hospital between Sep. 1999 and Mar. 2001 were divided into two groups according to the occurrence of restenosis on follow-up coronary angiogram: patients with restenosis (Group I : n=99, 59.5 10.8 years, M : F=77:22) and patients without restenosis (Group II : n=173, 58.8 10.2 years, M : F=131:42). IgG seropositivity and titer of CMV, C. pneumoniae, H. pylori, levels of C-reactive protein (CRP) were compared between two groups. RESULTS: There were no statistical differences in the seropositivity of CMV IgG, C. pneumoniae IgG, H. pylori IgG between two groups (Group I vs. II : 100% vs. 100%, 24.7% vs. 25.7%, 62.2% vs. 63.7% in group I vs. II respectively). Among angiographic parameters, low TIMI flow (TIMI 0 or I) was more common in Group I than in Group II (p=0.038). The patients with elevated CRP (>0.5 mg/dL) were more common in Group I than those in Group II (57.6% vs. 36.4%, p=0.001) and the value of CRP was higher in Group I than in Group II (3.3+/-5.8 mg/dL vs. 1.3+/-2.6 mg/dL, p=0.001). According to multiple logistic regression analysis, CRP was the only predictor of restenosis with odd ratio of 2.1169 (95% C.I. 1.2062-3.7154, p=0.009). CONCLUSION: The value of CRP is the most important predictor of restenosis after PCI.
