Usefulness of cyfra 21-1 as a tumor marker of lung cancer.
- Author:
Hyun Duk PARK
1
;
Hyun Sik JEONG
;
Jeung Sik PARK
;
Sung Ho LIM
;
Eun Jung LEE
;
Jung Won YUN
;
Su Suk JUNG
;
Ho Cheol SHIN
;
Seung Sei LEE
Author Information
1. Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Cyfra 21-1;
Lung cancer;
Tumor marker
- MeSH:
Adenocarcinoma;
Carcinoma, Non-Small-Cell Lung;
Carcinoma, Squamous Cell;
Humans;
Immunoradiometric Assay;
Keratin-19;
Keratins;
Lung Neoplasms*;
Lung*;
Small Cell Lung Carcinoma;
Biomarkers, Tumor
- From:Korean Journal of Medicine
2002;62(4):415-421
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Cytokeratins are epithelial markers whose expressions are not lost during malignant transformation. The utility of cytokeratin fragment (Cyfra) 21-1, a new tumor marker, was investigated in 110 patients with lung cancer. The aims of this study were to confirm sensitivity of Cyfra 21-1 in detecting non-small cell cancer, to assess the potential relationship between Cyfra 21-1 and disease stage of the lung cancer. METHODS: We measured serum levels of four tumor marker (NSE, CEA, SCC Ag, Cyfra 21-1) in 110 patients with lung cancer. The measurement of serum level of Cyfra 21-1 was performed with a cut off value of 3.3 ng/mL. An immunoradiometric assay was used to detect a fragment of the cytokeratin 19. The patients were grouped according to the stage of the disease and tumor type. RESULTS: Overall sensitivity of Cyfra 21-1 was relatively high (51.8%) than others tumor markers. Sensitivity of this marker was especially high for adenocarcinoma (63.2%) and squamous cell carcinoma (54.1%). In contrast, sensitiviy of Cyfra 21-1 was relatively low for small cell lung carcinoma (40.0%). Serum levels of Cyfra 21-1 were higher in advanced nonsmall cell lung cancer than early stage disease. CONCLUSION: We conclude that Cyfra 21-1 is a sensitive tumor marker of nonsmall cell lung cancer, especially adenocarcinoma and also may be a useful adjunctive marker for disease monitoring.
