Impairment of diastolic function in newly diagnosed non-insulin-dependent diabetes mellitus.
- Author:
Young Soo CHA
1
;
Hong Yup CHOI
;
Jin Kyoung PARK
;
Jun LEE
;
Sang Wook LIM
;
Dong Hoon CHA
;
Eun Kyoung HONG
;
Seok Won PARK
;
Yu Lee KIM
;
Yong Wook CHO
;
Sang Jong LEE
Author Information
1. Department of Internal Medicine, Pundang Cha Hospital, College of Medicine, Pochon Cha University, Sungnam, Korea.
- Publication Type:Original Article
- Keywords:
Diabetes mellitus;
Non-insulin-dependent;
Diastolic function;
Echocardiography
- MeSH:
Blood Pressure;
Body Surface Area;
Cholesterol;
Deceleration;
Diabetes Mellitus;
Diabetes Mellitus, Type 2*;
Echocardiography;
Fasting;
Healthy Volunteers;
Heart Failure;
Heart Rate;
Hospitals, General;
Humans;
Hyperinsulinism;
Hyperlipidemias;
Insulin;
Mortality, Premature;
Pulmonary Veins;
Relaxation;
Triglycerides
- From:Korean Journal of Medicine
2002;62(4):422-429
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Heart failure is one of the major cause of premature mortality and morbidity in diabetes mellitus. It has been well recognized that left ventricular diastolic dysfunction caused by autonomic neuropathy, hyperinsulinemia, hyperlipidemia might be a preceding underlying mechanism of heart failure in diabetes. Also, an impairment of diastolic function in early diabetic patients has been reported in some literature. So, we evaluated the diastolic function in newly diagnosed diabetics with echocardiography. METHODS: All patients with newly diagnosed NIDDM in Pundang Cha general hospital from December 1996 to June 1998 were enrolled (n=20). The 20 healthy volunteers comparable for age, sex, body surface area were enrolled as a control group. The echocardiography was performed in all patients before any treatment. Blood pressure, pulse rate, fasting and postprandial sugar and insulin level, serum total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol were also checked in all patients. RESULTS: There were no significant difference in blood pressure, pulse rate, total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol level between both groups. E and A ratio of mitral inflow and peak diastolic velocity of pulmonary vein flow were significantly decreased in NIDDM group compared with control group (p<0.01). But there were no significant difference in left ventricular mass index, isovolumic relaxation time, deceleration time and peak atrial reversal velocity. CONCLUSION: This study demonstrates that an impairment of left ventricular diastolic function occurs early in the NIDDM and investigation of diastolic function should be performed in the clinical evaluation of early diabetic patients.
