RNA Metabolism in T Lymphocytes
- Author:
Jin Ouk CHOI
1
;
Jeong Hyeon HAM
;
Soo Seok HWANG
Author Information
- Publication Type:Review Article
- From:Immune Network 2022;22(5):e39-
- CountryRepublic of Korea
- Language:English
- Abstract: RNA metabolism plays a central role in regulating of T cell-mediated immunity. RNA processing, modifications, and regulations of RNA decay influence the tight and rapid regulation of gene expression during T cell phase transition. Thymic selection, quiescence maintenance, activation, differentiation, and effector functions of T cells are dependent on selective RNA modulations. Recent technical improvements have unveiled the complex crosstalk between RNAs and T cells. Moreover, resting T cells contain large amounts of untranslated mRNAs, implying that the regulation of RNA metabolism might be a key step in controlling gene expression. Considering the immunological significance of T cells for disease treatment, an understanding of RNA metabolism in T cells could provide new directions in harnessing T cells for therapeutic implications.
