The Role of T Cells in Obesity-Associated Inflammation and Metabolic Disease
- Author:
Chan-Su PARK
1
;
Nilabh SHASTRI
Author Information
- Publication Type:Review Article
- From:Immune Network 2022;22(1):e13-
- CountryRepublic of Korea
- Language:English
- Abstract: Chronic inflammation plays a critical role in the development of obesity-associated metabolic disorders such as insulin resistance. Obesity alters the microenvironment of adipose tissue and the intestines from anti-inflammatory to pro-inflammatory, which promotes low grade systemic inflammation and insulin resistance in obese mice. Various T cell subsets either help maintain metabolic homeostasis in healthy states or contribute to obesity-associated metabolic syndromes. In this review, we will discuss the T cell subsets that reside in adipose tissue and intestines and their role in the development of obesity-induced systemic inflammation.
