Clinical and Genetic Characteristics of Korean Patients Diagnosed with Chronic Enteropathy Associated with SLCO2A1 Gene: A KASID Multicenter Study
- Author:
Hee Seung HONG
1
;
Jiwon BAEK
;
Jae Chul PARK
;
Ho-Su LEE
;
Dohoon PARK
;
A-Ran YOON
;
Soo Jung PARK
;
Sung Noh HONG
;
Seong-Joon KOH
;
Chang Kyun LEE
;
Bo-In LEE
;
Sung Wook HWANG
;
Sang Hyoung PARK
;
Seung-Jae MYUNG
;
Suk-Kyun YANG
;
Kyuyoung SONG
;
Byong Duk YE
;
On behalf of the IBD Research Group of the Korean Association for the Study of Intestinal Diseases
Author Information
- Publication Type:Original Article
- From:Gut and Liver 2022;16(6):942-951
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background/Aims:Chronic enteropathy associated with SLCO2A1 gene (CEAS), an inherited disease characterized by nonspecific intestinal ulcers, has emerged in the Japanese population via loss-of-function mutations in the SLCO2A1 gene. We aimed to investigate the clinical and genetic characteristics of Korean patients diagnosed with CEAS.
Methods:From July 2018 to July 2021, we performed Sanger sequencing of the SLCO2A1 gene in 46 patients with chronic intestinal ulcers. CEAS was confirmed based on known SLCO2A1 mutations. We summarized the clinical characteristics of patients with confirmed CEAS.
Results:Fourteen out of 46 patients (30.4%) had genetically confirmed CEAS, and two SLCO2A1variants were detected (splicing site variant c.940+1G>A and nonsense mutation [p.R603X] in SLCO2A1). Twelve patients (85.7%) were females and the median age at diagnosis of CEAS was 44.5 years. All patients presented with abdominal pain, and 13 patients (92.9%) presented with anemia (median hemoglobin, 9.6 g/dL). Ten patients (71.4%) had hypoalbuminemia (median, 2.7 g/dL). The most commonly involved site was the ileum (13/14, 92.9%). Manifestations of primary hypertrophic osteoarthropathy (PHO), such as digital clubbing, pachydermia, and periostosis were observed in five patients (28.6%) and two male patients and one female patient satisfied all major PHO diagnostic criteria.
Conclusions:The clinical and genetic characteristics of Korean patients with confirmed CEAS were similar to those reported in the literature. CEAS should be considered in the differential diagnosis for patients with unexplained chronic nonspecific ulcers of the small intestine.
