Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using 99mTc TRODAT-1
10.9758/cpn.2022.20.4.768
- Author:
Tsung-Hua LU
1
;
Shih-Hsien LIN
;
Huai-Hsuan TSENG
;
Yen Kuang YANG
;
Nan Tsing CHIU
;
Po See CHEN
Author Information
1. Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
- Publication Type:Brief Report
- From:Clinical Psychopharmacology and Neuroscience
2022;20(4):768-772
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:Bipolar disorder (BD) is characterized by the poor sleep quality. Whether the striatal dopamine transporter (DAT) availability is related to sleep quality among patients with BD is unclear.
Methods:Fifty-three euthymic patients with BD (24 BD-I and 29 BD-II) and sixty-eight healthy controls were enrolled. The Chinese Version of the Pittsburgh Sleep Quality Index (PSQI) was used, and the availability of DAT was assessed by single-photon emission computed tomography (SPECT) using [99mTc] TRODAT-1.
Results:The sleep disturbance component of the PSQI was significantly associated with the level of DAT availability among patients with BD.
Conclusion:The striatal dopaminergic activity that contributes to resilience to adversity was associated with sleep pattern among patients with BD.
