The Cumulative Effect of Antipsychotic Usage on Mortality in Schizophrenia: A Nationwide Population-based Cohort Study in Korea
10.9758/cpn.2022.20.3.573
- Author:
Gyurin KIM
1
;
Soo Jung RIM
;
Minkyung JO
;
Min Geu LEE
;
Se Jin PARK
;
Subin PARK
Author Information
1. Department of Research Planning, National Center for Mental Health, Seoul, Korea
- Publication Type:Brief Report
- From:Clinical Psychopharmacology and Neuroscience
2022;20(3):573-577
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:To investigate the cumulative effect of antipsychotics at different dosages on mortality in patients with schizophrenia.
Methods:We analyzed data from the Korean National Health Insurance System−National Sample Cohort covering the 2002−2013 period. We used Cox regression analysis to calculate hazard ratios for mortality risks according to cumulative antipsychotic exposure levels (low, moderate, and high).
Results:Our analyses revealed no significant association between antipsychotic exposure and mortality (either all-cause or cause-specific) in patients with schizophrenia.
Conclusion:Our results imply that the excess mortality of patients with schizophrenia is attributable to factors other than antipsychotic usage.
