Severity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers
10.7774/cevr.2022.11.1.121
- Author:
Hanna KLINGEL
1
;
Maike LAUEN
;
Alexander KRÜTTGEN
;
Matthias IMÖHL
;
Michael KLEINES
Author Information
1. Laboratory Diagnostic Center, University Hospital RWTH Aachen, Aachen, Germany
- Publication Type:Brief Communication
- From:Clinical and Experimental Vaccine Research
2022;11(1):121-124
- CountryRepublic of Korea
- Language:English
-
Abstract:
Knowledge about mRNA-1273 elicited T-cell response is limited. We investigated adverse reactions and interferon gamma release by specific T-cells among mRNA-1273 vaccinated health care workers. Seven to 13 weeks after complete vaccination low levels of specific T-cells were detected not correlating with antibody response. Severity of symptoms after first and number of symptoms after second immunization were associated with T-cell response. Assessment of T-cell response in addition to antibody response is crucial because even few specific T-cells could add to protection against infection. Investigation of mRNA-1273 induced inflammatory processes might help improve reactogenicity and immunogenicity.
