Association of CD40 gene polymorphisms and immune thrombocytopenic purpura in the adult Egyptian population
- Author:
Hend Nabil ELLITHY
1
;
Sherif Mohamed YOUSRY
;
Asmaa ABDEL-AAL
;
Lelian TAWADROS
;
Nouran MOMEN
Author Information
- Publication Type:ORIGINAL ARTICLE
- From:Blood Research 2022;57(3):229-234
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:The pathophysiology underlying primary adult immune thrombocytopenic purpura (ITP) has not yet been identified. However, many mechanisms affect the immune system, causing defective tolerance to self-platelets and megakaryocytes. Cluster of differentiation 40 (CD40) contributes to both humoral and cell-mediated immune responses.
Methods:This case‒control study was conducted to detect rs4810485G＞T and rs1883832C＞T polymorphisms of CD40 in Egyptian patients with persistent/chronic ITP to clarify their possible association with chronic disease evolution. This study included 50 patients with persistent/chronic ITP and 50 healthy controls. Genotyping was performed using the polymerase chain reaction‒restriction fragment length polymorphism technique.
Results:Genotyping of rs1883832 and rs4810485 revealed no statistically significant differences between the two groups. However, combined gene polymorphism genotyping showed a statistically significant difference between the two groups (P ＜0.01).
Conclusion:Our results indicate a strong association between the combined polymorphism of both genes and susceptibility to developing ITP among adult Egyptian patients. Targeting this pathway using novel therapeutic approaches is promising.
