The role of postoperative neutrophil-to-lymphocyte ratio as a predictor of postoperative major complications following total gastrectomy for gastric cancer
10.4174/astr.2022.103.3.153
- Author:
Jae Seung KWAK
1
;
Sung Gon KIM
;
Sang Eok LEE
;
Won Jun CHOI
;
Dae Sung YOON
;
In Seok CHOI
;
Ju Ik MOON
;
Nak Song SUNG
;
Seong Uk KWON
;
In Eui BAE
;
Seung Jae LEE
;
Seung Jae ROH
Author Information
1. Department of Surgery, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Korea
- Publication Type:ORIGINAL ARTICLE
- From:Annals of Surgical Treatment and Research
2022;103(3):153-159
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:This study was performed to investigate the role of the perioperative neutrophil-to-lymphocyte ratio (NLR) as an early predictor of major postoperative complications after total gastrectomy for gastric cancer.
Methods:This single-center, retrospective study reviewed consecutive patients with gastric cancer who underwent total gastrectomy at a single institution from March 2009 to March 2021. The postoperative complications were graded according to the Clavien-Dindo classification. We analyzed the patient demographics and surgical outcomes according to the grade of postoperative complications in the major complications group (≥grade III) and the no major complications group (
Results:Out of 212 patients (mean age, 64.1 years; 152 male [71.7%]), 63 (29.7%) underwent minimally invasive surgery. Twenty-five (11.8%) were in the major complications group and 187 (88.2%) were in the no major complications group. There was a significant difference in the NLR on POD 2 (16.54 vs. 8.83, P = 0.033) between the 2 groups. According to the receiver operating characteristic curve for the NLR on POD 2, the cutoff was calculated to be 9.6. In multivariate analysis, an NLR on POD 2 of ≥9.6 and an American Society of Anesthesiologists physical status classification of ≥III were statistically significant predictors of major postoperative complications.
Conclusion:Determination of the NLR on POD 2 is a simple and useful method for the early prediction of major complications after total gastrectomy for gastric cancer.
