The incidence and risk factors of extrapulmonary manifestations in Mycoplasma pneumoniae pneumonia
- Author:
Yoo Kyung PARK
1
;
You Na PARK
;
Ji Eun MOON
;
Hyo-Bin KIM
;
Meeyong SHIN
;
Eun LEE
;
Chul-Hong KIM
;
Ju Suk LEE
;
Yong Ju LEE
;
Bong-Seong KIM
;
Hyung Young KIM
;
Sungsu JUNG
;
Yunsun KIM
;
Sangyoung KIM
;
Chorong PARK
;
Ju-Hee SEO
;
Jung Yeon SHIM
;
In Suk SOL
;
Myongsoon SUNG
;
Dae Jin SONG
;
Young Min AHN
;
Hea Lin OH
;
Jinho YU
;
Kyung Suk LEE
;
Gwang Cheon JANG
;
Yoon-Young JANG
;
Hai Lee CHUNG
;
Eun Hee CHUNG
;
Sung-Min CHOI
;
Yun Jung CHOI
;
Man Yong HAN
;
Jin Tack KIM
;
Chang-Keun KIM
;
Hyeon-Jong YANG
Author Information
- Publication Type:ORIGINAL ARTICLE
- From:Allergy, Asthma & Respiratory Disease 2022;10(4):207-214
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:Mycoplasma pneumoniae pneumonia (MP) is a major cause of community-acquired pneumonia (CAP) in children and is associated with extrapulmonary manifestations (EPM). The incidence and risk factors for EPM in children are unknown.
Methods:This was a retrospective study involving 65,243 pediatric patients with CAP between 2010 and 2015 at 23 nationwide hospitals in South Korea. Medical records were reviewed to collect information regarding the clinical characteristics, radiological results, and laboratory findings. Logistic regression with multivariate analysis was performed to evaluate the risk factors associated with EPM in MP.
Results:The incidence of EPM was 23.9%, including elevation of liver enzymes (18.1%), mucocutaneous manifestations (4.4%), proteinuria (4.1%), cardiovascular and neurological manifestations (0.4%), hematologic manifestations (0.2%), and arthritis (0.2%). Statistical analysis showed that mucocutaneous manifestations significantly increased with elevated alanine aminotransferase (adjusted odds ratio [aOR], 3.623; 95% confidence interval [CI], 1.933-6.790) and atopic sensitization (aOR, 2.973; 95% CI, 1.615–5.475) and decreased with respiratory virus coinfection (aOR, 0.273; 95% CI, 0.084–0.887). Elevated liver enzymes were significantly associated with elevated lactate dehydrogenase (aOR, 3.055; 95% CI, 2.257–4.137), presence of pleural effusion (aOR, 2.635; 95% CI, 1.767–3.930), and proteinuria with respiratory virus coinfection (aOR, 2.245; 95% CI, 1.113–4.527).
Conclusion:Approximately 24% of pediatric patients with MP had various EPM. As the risk factors associated with each EPM were different, it is necessary to evaluate the various clinical aspects and findings of MP to predict and prepare for the occurrence of EPM.
